HORDB

ID: hor004133
Uniprot ID: Q99P86(24-105)
Protein name: Resistin-like beta
Gene name: Retnlb
Organism: Mus musculus (Mouse)
Family: Resistin/FIZZ family
Source: animal
Expression: Up-regulated in colon in response to a high-fat diet. Also up-regulated in obese mice mutant for the leptin receptor LEPR (db/db genotype). |Strongly expressed in colon, and at lower levels in ileum .
Disease: NA
Comments: NA
Taxonomy: Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0009617 response to bacterium
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: QCSFESLVDQRIKEALSRQEPKTISCTSVTSSGRLASCPAGMVVTGCACGYGCGSWDIRNGNTCHCQCSVMDWASARCCRMA
Length: 82(24-105)
Propeptide: MKPTLCFLFILVSLFPLIVPGNAQCSFESLVDQRIKEALSRQEPKTISCTSVTSSGRLASCPAGMVVTGCACGYGCGSWDIRNGNTCHCQCSVMDWASARCCRMA
Signal peptide: MKPTLCFLFILVSLFPLIVPGNA
Modification: NA
Glycosylation: NA
Mutagenesis: 2-2C->A: Fails to homodimerize.

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q8K1D8-F1.pdb

hor004133_AF2.pdb

hor004133_ESM.pdb

Mass:	1020700	Formula:	C356H576N112O118S14
Absent amino acids:		Common amino acids:	CS
pI:	7.82	Basic residues:	9
Polar residues:	37	Hydrophobic residues:	21
Hydrophobicity:	-8.41	Boman Index:	-13996
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	54.76
Instability Index:	3639.88	Extinction Coefficient cystines:	13115
Absorbance 280nm:	161.91